Mono definition3/28/2023 This agent has potent anti-tumor efficacy in mono and combination therapy in a broad range of cancers. (Monoclonal Antibody OVB3-PE, NCI Thesaurus) The antibody portion of the agent binds to human ovarian cancer cells the pseudomonas exotoxin, a 66 kDa protein belonging to a family of enzymes known as mono-(ADP-ribosyl) transferases, stops tumor cell protein synthesis by inactivating elongation factor 2 and disrupting protein synthesis. (Epstein-Barr virus protein can “switch on” risk genes for autoimmune diseases, National Institutes of Health) This syndrome, also known as “ mono” or the “kissing disease,” generally resolves with rest and only rarely causes serious complications. (Cytomegalovirus Infections, Centers for Disease Control and Prevention) It is related to the viruses that cause chickenpox and infectious mononucleosis ( mono). Upon intravenous administration of a microdose of carbon C 14 oxaliplatin, the oxaliplatin moiety covalently links to DNA and forms mono- and di-DNA adducts. It is converted in vivo to its mono-, di-, and triphosphate forms and is incorporated into DNA by competition with thymidine. Distinct Behaviors of Cu- and Ni-ZSM-5 Zeolites toward the Post-activation Reactions of Methane.Mono occurs most often in teens and young adults.Ĭordycepin is an adenosine analogue, which is readily phosphorylated to its mono-, di-, and triphosphate intracellularly.
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